A neuronal death model: overexpression of neuronal intermediate filament protein peripherin in PC12 cells |
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| Authors: | Wen-Ching Lee Yun-Yu Chen Daphne Kan Chung-Liang Chien |
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| Institution: | (1) Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Jen-Ai Road, Taipei, 100, Taiwan;(2) Center of Genomic Medicine, National Taiwan University, Jen-Ai Road, Taipei, 100, Taiwan |
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| Abstract: | Background Abnormal accumulation of neuronal intermediate filament (IF) is a pathological indicator of some neurodegenerative disorders.
However, the underlying neuropathological mechanisms of neuronal IF accumulation remain unclear. A stable clone established
from PC12 cells overexpressing a GFP-Peripherin fusion protein (pEGFP-Peripherin) was constructed for determining the pathway
involved in neurodegeneration by biochemical, cell biology, and electronic microscopy approaches. In addition, pharmacological
approaches to preventing neuronal death were also examined. |
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