Quantification of changes in enzyme activity induced by drug action |
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| Authors: | R. J. Trickey N. Woolf D. Rosen R. Williams |
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| Affiliation: | (1) Department of Histopathology, St George's Hospital Medical School, London, UK;(2) Biophysics Laboratory, Chelsea College, London, UK;(3) Present address: Department of Histopathology, Middlesex Hospital Medical School, London, UK;(4) Present address: Brain and Perception Laboratory, The Medical School, Bristol, UK |
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| Abstract: | Synopsis Following the administration of isoprenaline subcutaneously to rats, the proportion of myocardial muscle fibres stained by Formazan produced by succinate dehydrogenase activity was measured. Measurements were made manually and with a flying-spot microscope. Both methods gave the same results, but the automated system has advantages of speed.Paper given at the Royal Microscopical Society's European Histochemistry Meeting at Nottingham in September 1975. |
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