The cDNA for the heart/muscle isoform of bovine cytochrome c oxidase subunit VIa encodes a presequence. |
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| Authors: | E O Smith D M BeMent L I Grossman M I Lomax |
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| Institution: | Department of Anatomy and Cell Biology, University of Michigan Medical School, Ann Arbor 48109-0616. |
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| Abstract: | We have used mixed oligonucleotide probes to isolate a cDNA for the heart/muscle isoform of cytochrome c oxidase (COX) subunit VIa (COX VIa-H) from a bovine heart cDNA library in lambda gt10. This cDNA, and a second one isolated upon rescreening, predict a 97 amino acid COX VIa precursor protein comprised of a 12 amino acid, basic presequence plus an 85 residue mature VIa protein. The presence of a presequence contrasts with the rat heart COX VIa cDNA. |
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