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UK-73,093: A non-peptide neurotensin receptor antagonist |
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| Authors: | R. Michael Snider Dennis A. Pereira Kelly P. Longo Ralph E. Davidson Frederic J. Vinick Kirsti Laitinen Ece Genc-Sehitoglu Jacqueline N. Crawley |
| Affiliation: | Central Research Division, Pfizer Inc, Groton, CT 06340 U.S.A. a National Institute of Mental Health, Bethesda MD 20892 U.S.A. |
| Abstract: | UK-73,093 was identified in a screening program as a compound able to displace [3H]-neurotensin from its bovine brain receptor. We describe the discovery of this compound, species differences in receptor affinity and its characterization as a functional neurotensin antogonist in vitro and in vivo. |
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