Focus: A Multifaceted Battle Against Cancer: Basal Cell Carcinoma: Pathogenesis,Epidemiology, Clinical Features,Diagnosis, Histopathology,and Management |
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Authors: | Alexander G. Marzuka Samuel E. Book |
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Affiliation: | aDepartment of Dermatology, Yale School of Medicine, New Haven, Connecticut;bDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut |
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Abstract: | Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease. The pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management of BCC will be discussed in this review. |
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Keywords: | basal cell carcinoma, BCC, electrodesiccation and curettage, ED& C, surgical excision, Mohs surgery |
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