The genomic rate of adaptive evolution |
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Authors: | Eyre-Walker Adam |
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Affiliation: | National Evolutionary Synthesis Center, Durham, NC 27705, USA. a.c.eyre-walker@sussex.ac.uk |
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Abstract: | The role of positive darwinian selection in evolution at the molecular level has been keenly debated for many years, with little resolution. However, a recent increase in DNA sequence data and the development of new methods of analysis have finally made this question tractable. Here, I review the current state-of-play of the field. Initial estimates in Drosophila suggest that approximately 50% of all amino acid substitutions, and a substantial fraction of substitutions in non-coding DNA, have been fixed as a consequence of adaptive evolution. Estimates in microorganisms are even higher. By contrast, there is little evidence of widespread adaptive evolution in our own species. |
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