Selection for the compactness of highly expressed genes in <Emphasis Type="Italic">Gallus gallus</Emphasis> |
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Authors: | You S Rao Zhang F Wang Xue W Chai Guo Z Wu Ming Zhou Qing H Nie Xi Q Zhang |
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Institution: | (1) Department of Biological Technology, Jiangxi Educational Institute, Nanchang, Jiangxi, China;(2) Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China |
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Abstract: | Background Coding sequence (CDS) length, gene size, and intron length vary within a genome and among genomes. Previous studies in diverse
organisms, including human, D. Melanogaster, C. elegans, S. cerevisiae, and Arabidopsis thaliana, indicated that there are negative relationships between expression level and gene size, CDS length as well as intron length.
Different models such as selection for economy model, genomic design model, and mutational bias hypotheses have been proposed
to explain such observation. The debate of which model is a superior one to explain the observation has not been settled down.
The chicken (Gallus gallus) is an important model organism that bridges the evolutionary gap between mammals and other vertebrates. As D. Melanogaster, chicken has a larger effective population size, selection for chicken genome is expected to be more effective in increasing
protein synthesis efficiency. Therefore, in this study the chicken was used as a model organism to elucidate the interaction
between gene features and expression pattern upon selection pressure. |
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