In vitro histamine H2-antagonist activity of the novel compound HUK 978 |
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Authors: | J D Coombes D B Norris T J Rising B C Ross A Steward |
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Affiliation: | Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton, Milton Keynes, MK7 7AJ, England |
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Abstract: | Histamine stimulated adenylate cyclase from guinea-pig fundic mucosa and 3H-tiotidine binding in guinea-pig cerebral cortex were used to assess the in-vitro histamine H2-activity of the novel H2-antagonist HUK 978. The results showed that HUK 978 was a more potent H2-antagonist than either cimetidine or ranitidine. HUK 978 was also shown to be devoid of activity at the histamine H1-receptor, the muscarinic receptor and the alpha and beta-adrenergic receptors. |
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Keywords: | To whom correspondence should be addressed. |
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