The structure of human collapsin response mediator protein 2, a regulator of axonal growth |
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Authors: | Stenmark Pål Ogg Derek Flodin Susanne Flores Alex Kotenyova Tetyana Nyman Tomas Nordlund Pär Kursula Petri |
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Institution: | Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. |
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Abstract: | Axonal growth cone guidance is a central process in nervous system development and repair. Collapsin response mediator protein 2 (CRMP-2) is a neurite extension-promoting neuronal cytosolic molecule involved in the signalling of growth inhibitory cues from external stimuli, such as semaphorin 3A and the myelin-associated glycoprotein. We have determined the crystal structure of human tetrameric CRMP-2, which is structurally related to the dihydropyriminidases; however, the active site is not conserved. The wealth of earlier functional mapping data for CRMP-2 are discussed in light of the three-dimensional structure of the protein. The differences in oligomerisation interfaces between CRMP-1 and CRMP-2 are used to model CRMP-1/2 heterotetramers. |
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Keywords: | collapsin response mediator protein 2 crystal structure growth cone guidance neuronal regeneration tetramer TIM barrel |
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