Effects of distant transplantation of the embryoniclocus coeruleus on the learning process and memory in rats |
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Authors: | D A Bevz’yuk |
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Institution: | (1) Ukrainian Institute of Clinical and Experimental Neurology and Psychiatry, Ministry of Public Health of Ukraine, Khar’kov, Ukraine |
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Abstract: | We studied the effects of distant transplantation (in the neck region, subcutaneously) of the embryoniclocus coeruleus tissue on the indices of the learning process and memory in recipient rats. The patterns of learning for a conditioned emotional
avoidance reaction (CEAR) allowed us to classify experimental animals into two groups, with successful and hampered formation
of the CEAR sterotype, respectively. In the first-group rats, after formation of this stereotype we electrolytically injured
the frontal brain cortex, which resulted in some worsening of the CEAR reproduction and quality of differentiation. Distant
transplantation of thelocus coeruleus tissue provided effective recovery of the CEAR reproduction in the first-group animals, while rather fast and successful
formation of the CEAR stereotype became possible in the second group of rats. It is concluded that the transplantedlocus coeruleus tissue preserves its viability, undergoes differentiation, and exerts a stimulating influence on the learning process and
memory formation (probably, due to activation of noradrenergic links in the brain systems). |
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