Efficiency of polysaccharide translam for early treatment of acute radiation illness |
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Authors: | Chertkov K S Davydova S A Nesterova T A Zviagintseva T N Eliakova L A |
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Institution: | State Research Centre of Russia-Institute of Biophysics, Moscow. ibphgen@rcibph.dol.ru |
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Abstract: | Antiradiation therapeutic efficiency of translam (1-->3; 1-->6-beta-D-glucan) produced by enzymatic synthesis out of laminarin, polysaccharide of Laminaria cychorioides, has been studied in four animal species (mice, guinea-pigs, dogs, monkeys). A stable curative effect has been observed following its administration within first 24 h after radiation exposure at doses that cause acute radiation sickness (about LD90). The preparation is nontoxic and has a broad therapeutic range which permits its practical application. |
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