Influence of dietary lead on fluoride bioavailability in the rat |
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Authors: | Florian L Cerklewski James W Ridlington |
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Institution: | (1) Department of Foods and Nutrition, College of Home Economics, Oregon State University, 97331 Corvallis, OR |
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Abstract: | A factorial experiment was conducted with weanling rats fed a purified diet to determine the influence of dietary lead (0
or 100 ppm) as either lead acetate or lead carbonate on fluoride bioavailability (2 or 10 ppm as sodium fluoride). During
the 6-wk study, both forms of lead depressed weight gain, regardless of the fluoride level, despite the fact that food intake
was similar for all treatment groups. Both forms of lead produced a small, but significant, reduction in femur and second
molar fluoride. This effect, however, could only be demonstrated in rats fed diets containing 10 ppm fluoride, indicating
a significant interaction between lead and fluoride for these indices of fluoride bioavailability. This interactive effect
between fluoride and lead was also demonstrated for apparent fluoride absorption. Both forms of dietary lead significantly
increased the lead concentration of plasma, femur, liver, and kidney, and both forms of lead significantly increased the urinary
excretion of delta-aminolevulinic acid. The level of dietary fluoride failed to influence these measurements. We therefore
conclude that, although small amounts of dietary lead reduce fluoride bioavailability, small amounts of dietary fluoride do
not appear to significantly influence the utilization of dietary lead. |
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Keywords: | Fluoride absorption and utilization fluoride-lead interaction femur and molar fluoride tissue lead lead toxicity |
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