Inheritance patterns of maternal alleles in imprinted regions of the mouse genome at different stages of development |
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| Authors: | Sylvie Croteau Moises Freitas Andrade Fleur Huang Celia MT Greenwood Kenneth Morgan Anna K Naumova |
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| Institution: | (1) Department of Obstetrics and Gynecology, Royal Victoria Hospital, Women's Pavilion, F3.36, 687 Pine Ave. West, Montreal, QC, Canada, H3A 1A1, CA;(2) Department of Medicine, McGill University, Montreal, Quebec, Canada, CA;(3) Department of Human Genetics, McGill University, Montreal, Quebec, Canada, CA;(4) Department of Epidemiology and Biostatistics, McGill University, and the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada, CA |
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| Abstract: | Deviations from Mendelian 1:1 transmission ratio have been observed in mice and humans. With few exceptions, the mechanism
leading to transmission-ratio distortion (TRD) remains obscure. We proposed that a genomic imprinting mechanism plays a key
role in the genesis of grandparental origin-dependent TRD (Naumova et al. 2001). To further test this hypothesis, we analyzed
the transmission of grandparental alleles at three imprinted regions of the mouse genome known to contain genes required for
embryo development. We found and replicated moderate (58%: 42%) TRD in favor of grandmaternal alleles in the imprinted region
of maternal distal Chromosome (Chr) 12 among female offspring. Comparison of transmission ratios at the distorted region of
Chr 12 among 3-week-old mice with those in embryos suggests that the distortion in favor of grandmaternal alleles is owing
to postimplantation embryo loss. The absence of grandparental origin-dependent TRD for maternal Chr 6 and 7 implies that the
relationship between TRD and imprinting is complex. Most likely, multiple conditions are required for TRD to occur.
Received: 20 June 2001 / Accepted: 28 August 2001 |
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