Androgen binding protein, sperm production, semen output and LH and testosterone profiles in young postpubertal bulls |
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Authors: | Le Cacheux P Carreau S Drosdowsky M Nibart M Abdel Malak G Thibier M |
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Institution: | 1. Laboratoire de Biochimie - CHU Côte de Nacre-14040 Caen - France.;2. Laboratoire d''Hormonologie - UNCEIA - 13, rue Jouët 94703 Maisons-Alfort - France.;3. UNCEIA 78850 Thiverval-Grignon - France.;4. Institut National Agronomique Paris-Grignon 78850 Thiverval-Grignon - France. |
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Abstract: | An androgen binding protein (ABP), which binds 5alpha-dihydrotestosterone with high affinity (Ka = 0.3 x 10(9) M(-1)), has been demonstrated in testicular and epididymal cytosols of 5 young post pubertal bulls (15-17 months old) of the Montbeliarde dairy breed. Simultaneously, daily sperm production (DSP), semen output and plasma LH and testosterone concentrations (from frequent samplings) were determined. ABP levels were 21 fmoles/mg protein in testis and 59, 22 and 43 fmoles/mg, respectively, in caput, corpus and cauda epididymis. Mean DSP, per gram of testis, was 16.6 x 10(6) spermatozoa, and the mean sperm output was approximately 1.5 x 10(9) spermatozoa per ejaculate. Mean LH and testosterone levels were 1.5 ng/ml and 2.1 ng/ml, respectively. One bull (882) was clearly distinguishable from the others, in showing higher ABP and testosterone levels together with a lower daily sperm production. Results of this study may (1) suggest a physiological role of ABP in sperm epididymal maturation and (2) give a new parameter in the evaluation of individual bulls testicular function. |
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Keywords: | Reprints should be addressed to M Thibier |
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