Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects |
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Authors: | Morales-Bozo Irene Rojas Gonzalo Ortega-Pinto Ana Espinoza Iris Soto Lilian Plaza Anita Lozano Carla Urzúa Blanca |
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Institution: | Oral Biology and Oral Biochemistry Laboratory, Department of Basic and Communitarian Sciences, Faculty of Dentistry, University of Chile, Chile, Santiago, Chile. imorales@uchile.cl |
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Abstract: | doi: 10.1111/j.1741‐2358.2012.00626.x Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects Objective: To evaluate the efficacy of two new mouthrinses in the reduction of xerostomía‐associated symptomatology. Background: Xerostomia is a common chronic health condition that affects a great number of adults and significantly deteriorates quality of life, such that treatment is necessary. Materials and methods: Sixty‐seven adult subjects of both sexes presenting xerostomia of diverse origin were selected. Mouthrinses were tested using a double‐blind, randomized, cross‐over clinical trial with an intervining wash out period. Results: The 100% of subjects presented sensation of dry mouth, and 86% stated sensation of thick saliva. Burning tongue sensation, need to drink liquids to swallow and the sensation of swallowing difficulty were recorded in more than 50% of the patients. The most frequent pathologies in the sample were depression, arthritis, and arterial hypertension. Results of the clinical tests showed that mouthrinse 1 relieves sensation of dry mouth, need to drink liquids, and swallowing difficulty. In contrast, mouthrinse 2 relieves only latter two symptoms. Both rinses were more effective in relieving xerostomía‐associated symptomatology in patients taking 3 or more medicines simultaneously. Conclusion: Both mouthrinses were effective in relieving various xerostomia symptoms, could be distributed at a low cost, thereby improving the quality of life of population affected. |
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Keywords: | xerostomia mouthwash palliative management clinical trial |
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