Synthesis of serum thymic factor (FTS) and two analogs |
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| Authors: | Goro Tsukamoto Koji Iuchi Masahiro Nitta Takashi Nose and Yoshio Okada |
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| Institution: | (1) Pharmaceutical Research Center, Kanebo, Ltd., Osaka, Japan;(2) Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Kobe, Japan |
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| Abstract: | Serum thymic factor (FTS) and Gln1]-FTS were synthesized by fragment condensation using the azide procedure. d-Ala6]-FTS was prepared by stepwise amino acid condensation in combination with fragment condensation on solid-phase resin. Synthetic FTS and Gln1]-FTS both enhanced the delayed-type hypersensitivity (DTH) level to sheep red blood cells (SRBC) in mice at a dose of 0.1 ng/mouse per day, while a dose of 1.0 ng/mouse per day of d-Ala6]-FTS was needed for the enhancement reaction. |
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| Keywords: | serum thymic factor analogs chemical synthesis biological activity delayed-type hypersensitivity |
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