A partial BRCA1 sequence homology mapping to 4q28. |
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| Authors: | I Stec M van Vliet R van Eijk H Meijers K H Kroeze J G Dauwerse G J van Ommen C J Cornelisse J T den Dunnen P Devilee |
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| Affiliation: | Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. I.Stec@LUMC.nl |
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| Abstract: | Using a BRCA1 cDNA probe in Southern analysis, we detected a sequence of 348 bp on 4q28 that is homologous to the 3' end of BRCA1. A 28-kb sequence contig has been assembled spanning the homologous region, which we designated BRCA1-h. An open reading frame was identified encoding a sequence of 82 amino acids; 22 of the last 23 amino acids are identical to the last 23 residues of BRCA1. BLAST-searches, RT-PCR and RACE-experiments have been unable to provide evidence that BRCA1-h is part of an expressed gene. |
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