Pulmonary formation of prostacyclin in man |
| |
Authors: | A Edlund W Bomfim L kaijser C Olin C Patrono E Pinca Wennmalm |
| |
Institution: | 5. Department of Clinical Physiology, Huddinge University Hospital, S-141 86 Huddinge, Sweden;4. Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden;2. Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden |
| |
Abstract: | The pulmonary formation of prostacyclin (PGI2), as reflected by the difference in concentration of pulmonary and systematic arterial radioimmunoassayed 6-keto-PGF1α, was determined in six healthy waking subjects. The systematic arterial 6-keto-PGF1α levels were low (50 pg/ml), and no evidence of pulmonary formation and release of the compound was noted. In other experiments systemic arterial 6-keto-PGF1α levels were determined in patients prior to and during artificial ventilation, as well as during and after occlusion of the pulmonary circulation (extra-corporeal circulation, ECC). The arterial 6-keto-PGF1α concentration prior to artificial ventillation was 17±4 pg/ml, i.e. within the range observed in the healthy subjects. During artificial ventilation the arterial levels of 6-keto-PGF1α increased to 191±21 pg/ml, suggesting that pulmonary formation of PGI2 was stimulated. In the patients subjected to ECC with occluded pulmonary circulation the arterial content of 6-keto-PGF1α was stabilised at an elevated level (120−170 pg/ml). Following re-establishment of the pulmonary circulation the arterial concentrations of 6-keto-PGF1α increased markedly, to 284±50 pg/ml. It is suggested that the basal pulmonary formation of PGI2 in man is low or non-existent, and that enhanced formation of the compound in the lungs is a consequence of intervention with normal pulmonary ventilation or perfusion. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|