Inhibition of gap-junctional intercellular communication between Chinese hamster lung fibroblasts by di(2-ethylhexyl) phthalate (DEHP) and trisodium nitrilotriacetate monohydrate (NTA) |
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| Authors: | A Russell Malcolm Lesley J Mills |
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| Institution: | (1) Environmental Research Laboratory, U.S. EPA, Narragansett, Rhode Island;(2) Science Applications International Corporation, Narragansett, Rhode Island;(3) Environmental Research Laboratory, U.S. EPA, 02882 Narragansett, RI |
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| Abstract: | Di(2-ethylhexyl)phthalate and trisodium nitrilotriacetate monohydrate, two apparently nongenotoxic carcinogens, were tested for effects on gap-junctional communication between Chinese hamster V79 lung fibroblasts. Both compounds inhibited gap-junctional communication in a concentration-dependent manner. The inhibiting effects of these chemicals on gap-junctional communication in vitro correlate with their tumor-promoting activity. Such results further support the hypothesis that inhibition of gap-junctional communication is an in vitro biomarker for some tumor-promoting chemicals.Abbreviations CAS
Chemical Abstracts Service
- DEHP
di(2-ethylhexyl)phthalate
- GJIC
gap-junctional intercellular communication
- NTA
trisodium nitrilotriacetate monohydrate |
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| Keywords: | cell culture di(2-ethylhexyl)phthalate gap-junctional intercellular communication HGPRT hypoxanthine-guanine phosphoribosyl transferase trisodium nitrilotriacetate monohydrate tumor promotion |
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