Interactions between nitrogen oxide-containing compounds and peripheral benzodiazepine receptors |
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Authors: | E Moret I P Gerothanassis R N Hunston J Lauterwein |
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Institution: | Institut de Chimie Organique, Université de Lausanne, Switzerland. |
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Abstract: | Nitrogen oxide-containing compounds displaced the peripheral benzodiazepine ligand 3H]Ro5-4864 from guinea pig membrane preparations. Sodium nitroprusside (SNP) was the most potent (IC50 = 5.61 ± 1.72 × 10?5 M). Moreover, its ability to bind to these receptors showed marked tissue variability (heart> kidney cerebral cortex). When tested on rat atrium, SNP by itself had no effect on basal inotropy or the increase in inotropy induced by (?)-S-BAY K 8644. In contrast, Ro5-4864 potentiated the marked increase in inotropy induced by (?)-S-Bay K 8644, and SNP completely abolished the potentiation of inotropy observed with Ro5-4864. Since peripheral benzodiazepine receptors are associated with calcium mobilization in the heart, these findings may indicate that some of the clinical effects of nitric oxide-generating drugs could be mediated by these receptors. |
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Keywords: | Benzodiazepine receptor peripheral Sodium nitroprusside (Rat atrium Guinea pig heart) |
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