Vanillic acid, a metabolite of 4-hydroxy-3-methoxyphenylglycol and 4-hydroxy-3-methoxymandelic acid in man |
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Authors: | Göran Mådh |
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Affiliation: | Department of Alcohol and Drug Addiction Research, Karolinska Institutet, Stockholm, Sweden |
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Abstract: | Abstract: 4-Hydroxy-3-methoxyphenylglycol (HMPG) labelled with 14C was used to study the metabolic fate of HMPG in six healthy volunteers. Besides conjugation and oxidation to 4-hydroxy-3-methoxymandelic acid (HMMA, VMA) a minor portion, 8.4 ± 1.1% (mean ± SEM) was excreted as 14C-labelled vantllic acid (VA). To study if VA was formed from HMPG or HMMA (VMA), deuterium-labelled HMPG ([2H3]HMPG) and HMMA ([2H6]HMMA) were simultaneously injected intravenously to seven healthy volunteers. The recovery of [2H3]VA from [2H3]HMPG was 8.3 ± 2.1% and the recovery of [2H6]VA from [2H6]HMMA was 9.0 ± 2.1%. The 2H-labelled VAs were probably formed by a decar boxylation reaction, in the case of HMPG after previous oxidation to HMMA. |
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Keywords: | Norepinephrine Epinephrine 4 Hydroxy 3-methoxyphenylglycol 4 Hydroxy-3-methoxymandelic acid Vanillic acid Gas chromatography mass spectrometry |
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