Bilateral transverse sinus thrombosis secondary to a homozygous C677T MTHFR gene mutation |
| |
Authors: | Kanaan Ziad M Mahfouz Rami Taher Ali Sawaya Raja A |
| |
Affiliation: | Department of Internal Medicine, Faculty of Medicine, Wayne State University, Detroit, Michigan. |
| |
Abstract: | We describe the case of a previously healthy young man who presented with headache, diplopia, nausea, vomiting, and bilateral papilledema. Magnetic resonance venography of the brain revealed thrombosis of the right transverse sinus. Blood tests showed elevated homocysteine levels, and coagulation studies revealed a homozygous C677T mutation and a heterozygous A1298C mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. The patient had no other etiology for venous thrombosis. We recommend screening patients who present with sinus thrombosis for MTHFR gene mutations. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|