高血压患者脉搏波参数与脉搏波传导速度的相关性研究

目的:探讨高血压患者脉搏波参数与脉搏波传导速度的相关性,为从脉图上辨识高血压病及脉搏波参数的拓展应用提供参考。方法:选择2012年6月至2013年6月在北京安贞医院和北京人民医院门诊和住院确诊的原发性高血压患者32例作为实验组,并招募健康成人志愿者29例作为对照组。利用中医四诊合参辅助诊疗仪与皮尺分别采集两组受试者的左侧寸口脉图信息和主动脉至桡动脉的血管长度,计算脉搏波参数及脉搏波传导速度,采用方差分析和皮尔逊简单相关的统计方法分析高血压患者不同的脉搏波参数与其脉搏波传导速度的相关性。结果:与对照组比较,实验组的PWV显著升高,有显著性差异(P0.05)。实验组H2/H1明显高于对照组(P0.05),但H4/H1、T1/T、T2/T比值均显著低于对照组(P0.05),差异均有显著性意义(P0.05)。高血压患者的H2/H1、T1/T、T2/T、H4/H1均与其PWV相关,其中H2/H1与PWV呈显著正相关(P0.05),T1/T、T2/T与PWV呈显著负相关(P0.05),H4/H1与PWV呈一般正相关(P0.05)。结论:高血压患者的脉搏波参数与脉搏波传导速度具有显著相关性,且潮波出现的幅值与脉搏波传导速度有显著正相关;脉搏波上升支和潮波的时值与脉搏波传导速度具有显著负相关,重搏波相对高度与脉搏波传导速度具有一般相关关系,因而可通过脉搏波参数的变化了解高血压患者血管弹性的状态。

Correlative Research on the Parameters of Pulse Wave and Pulse Wave Conduction Velocity of Patients with Hypertension

Objective:To discuss the correlation of pulse wave parameters and pulse wave conduction velocity, and provide a reference for identifying hypertension from pulse diagram and expanding the application range of pulse wave parameters.Methods:32 cases of patients diagnosed as essential hypertension in Beijing An-Zhen hospital and Beijing people''s hospital outpatient and hospitalization between June 2012 and June 2013 were selected as the experimental group. 29 cases of healthy adult volunteers were recruited as the healthy control group. The left radial artery pulse information and the length of blood vessel from aorta to radial artery of two groups was detected using TCMfour diagnosis auxiliary apparatus and tape measure, and the correlation of parameters of pulse wave with pulse wave conduction velocity of patients with hypertension were analyzed by statistical method.Results:Compared with the healthy control group, the PWV value of hypertension group was significantly increased (P<0.05). H2/H1 in hypertension group was obviously higher than that of healthy controls (P<0.05), but the value of H4/H1, T1/T, T2/T in hypertension group were all significantly lower than those of the healthy controls (P<0.05). Among hypertension patients, the value of H2/H1, T1/T, T2/T and H4/H1 were associated with PWV. Moreover, H2/H1 and PWV was significantly positively correlated (P<0.05). T1/T and T2/T had a significant negative correlation with PWV (P<0.05). H4/H1 and PWV was generally positively correlated (P<0.05).Conclusion:The pulse wave parameters of hypertension patients and pulse wave conduction velocity had significant correlation, and the amplitude of tidal wave had significant positive correlation with pulse wave conduction velocity; pulse wave of rising and tidal wave duration had significant negative correlation with pulse wave conduction velocity, dicrotic wave relative height and pulse wave conduction velocity had a general relationship. Thus, the state of blood vessel elasticity could be evaluated by the change of pulse wave parameters.