| TET蛋白去甲基化作用的相关研究进展 |
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| 引用本文： | 李惠晨 叶明翔 侯赟 赖晓凤 马勇政 韦伊芳 张健. TET蛋白去甲基化作用的相关研究进展[J]. 现代生物医学进展, 2014, 14(27): 5361-5364 |
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| 作者姓名： | 李惠晨 叶明翔 侯赟 赖晓凤 马勇政 韦伊芳 张健 |
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| 作者单位： | 第四军医大学基础部生物化学与分子生物学教研室;第四军医大学学员旅 |
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| 基金项目： | 国家自然科学基金项目（81372390） |
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| 摘 要： | TET(ten-eleven translocation)蛋白属于酮戊二酸和Fe2+依赖的双加氧酶,能够产生催化氧化作用。在TET蛋白家族的催化氧化作用下5-甲基胞嘧啶(5-methylcytosine,5mC)可转化为5-羟甲基胞嘧啶(5-hydroxymethylcytosine,5hmC),并可进一步转化为5-甲酰胞嘧啶(5-formylcytosine,5fC)和5-羧基胞嘧啶(5-carboxylcytosine,5caC)。TET蛋白在DNA胞嘧啶的去甲基化、胚胎发育和基因重新编码等过程都存在重要作用,其中TET蛋白参与DNA胞嘧啶的去甲基化过程的作用机制一直是研究热点,另外,有研究发现TET与肿瘤的发生也存在联系,可能成为新的肿瘤分子标志。
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| 关 键 词： | TET蛋白 DNA去甲基化 肿瘤 |
The Research Progress of TET Proteins on DNA De-methylation |
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| LI Hui-chen,YE Ming-xiang,HOU Yun,LAI Xiao-feng,MA Yong-gan,WEI Yi-fang,ZHANG Jian. The Research Progress of TET Proteins on DNA De-methylation[J]. Progress in Modern Biomedicine, 2014, 14(27): 5361-5364 |
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| Authors: | LI Hui-chen YE Ming-xiang HOU Yun LAI Xiao-feng MA Yong-gan WEI Yi-fang ZHANG Jian |
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| Abstract: | TET (ten-eleven translocation) proteins belong to alpha-ketoglutaric acid (KG) and Fe2+-dependent dioxygenasesinwhich can catalyze an oxidative process. The 5-methylcytosine (5mC) can be converted to 5-hydroxy-methylcytosine (5hmC) by TETproteins family, and can successively be oxidized to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in DNA. The TET proteinshave an important role in DNA de-methylation, embryonic development and reprogramming. The role of TET proteins in DNAde-methylation has been a hot research. Further, studies have found that TET proteins also have an important role in cancer and TETproteins may become a new molecular marker of tumor. |
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| Keywords: | TET proteins DNA de-methylation Tumor |
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