中老年男性缺血性脑血管病与阻塞性睡眠呼吸暂停综合症的临床相关性分析

目的:对中老年男性缺血性脑血管病合并阻塞性睡眠呼吸暂停综合症(obstructive sleep apnea,OSA)的相关性及其危险因素进行临床分析。方法:选择中老年男性急性脑梗死患者(acute cerebral infarction,ACI)40例,短暂性脑缺血发作患者(transient ischemic attack,TIA)36例及健康对照组患者36例用多导睡眠呼吸监测仪进行监测,对患有OSA的患者根据睡眠呼吸暂停低通气指数(apnea hypopnea index,AHI)分成轻中重三组,并对其临床指标及危险因素进行分析。结果:ACI组(15.3±12.3)和TIA组(14.7±10.4)患者AHI显著高于对照组(8.2±6.6,P0.01)。OSA在各组中的发病率分别为60.0%,52.8%和22.2%,与对照组有显著差异。缺血性脑血管病患者的体重指数(BMI),血糖,纤维蛋白原(FIB),胆固醇水平(CHOL),高密度脂蛋白(HDL)以及烟酒等不良嗜好与OSA呈正相关。中重度OSA患者缺血性脑血管病的发病率显著高于轻症患者(P0.01)。结论:OSA是影响老年男性缺血性脑血管病发病的重要因素,其严重程度可能与缺血性脑血管病成正相关。

The Correlation Analysis of Middle Aged and Old Male with Ischemic Cerebrovascular Disease and Obstructive Sleep Apnea Syndrome

Objective:To investigate the relationship between the ischemic cerebrovascular disease and the obstructive sleep apnea syndrome (OSA) and to analyze the risk factors of them.Methods:40 old male patients at the age of medium with the acute cerebral infarction(ACI), 36 patients with transient ischemic attack (TIA) and another 36 age-matched healthy people were selected and detected by polysomnography (PSG). Then the patients with OSA were divided into three groups and the clinical indicators and risk factors were analyzed.Results:The mean level of AHI was (14.7± 10.4) in TIA and (15.3± 12.3) in ACI which was significantly higher than those of the controls (8.2± 6.6; P<0.01). The prevalences of OSA were 60.0% in ACI, 52.8% in TIA and 22.2% in controls. The body mass indicts (BMI), blood sugar, fibrinogen, cholesterol, high density lipoprotein, smoke and alcohol of patients with OSA were significantly higher than those of the patients without OSA. The incidence of ischemic cerebrovascular diseases happened to the patients with OSA who were suffered from the moderate to the severe were higher than those of the mild ones.Conclusion:OSA is associated with cerebrovascular disease in middle aged and old male patients. The severity of OSA maybe associated with ischemic cerebrovascular disease.