骨髓间充质干细胞在大鼠实验中的移植途径及比较

骨髓间充质干细胞是具有自我更新能力和分化潜能的一类成体干细胞,经过局部微环境的诱导,可在体内外进行扩展,到晚期可分化成为多种细胞系。当组织受损伤时,可迅速到达损伤部位,分化为特异的组织细胞,参与组织修复。骨髓间充质干细胞这种惊人的分化及组织修复能力,为治疗退行性疾病和器官损伤性疾病提供广阔前景,故成为科研热点。国内外相关实验研究多以大鼠为动物模型,而骨髓间充质干细胞如何进入大鼠体内并定植,是实验成功的重要前提。因此如何找到最合适、最安全的移植途径将骨髓间充质干细胞有效地移植进入大鼠疾病模型体内的受损区域,是研究者关心的重点。本文就目前骨髓间充质干细胞在大鼠实验中不同移植途径进行综述,并比较各种途径的优缺点,希望能对临床科研工作提供参考,并期待能有更成熟的移植手段来推动骨髓间充质干细胞实验研究的进展。

Comparison of the Transplantation Channel of Bone MarrowMesenchymal StemCells in the Experiment of Rats*

ABSTRACT:Bone marrow mesenchymal stemcells are kinds of adult stemcells that have self-renewal capacities and differentiationpotentials. They can be expanded and induced by local microenviroment, either in vitro or in vivo, to terminally differerntiate intomultiple lineages. When tissue damages, they can move to injury quickly and differentiate into specific tissues and cells, participate inrepair. The amazing abilities of differentiation and tissue repair about bone marrow mesenchymal stem cells provide broad prospects fordegenerative disease and organ damage disease, so they become hot spot of scientific research. Experimental researches of bone marrowmesenchymal stem cells at home and abroad often adopt animal models for rats. How to enter and engraftment in rat becomes animportant prerequisite for success in the experiment about bone marrow mesenchymal stem cells. So how to transplant bone marrowmesenchymal stem cells into the damaged area of the disease model in rats with the most suitable and safest way is the key thatresearchers concerned. In this paper, different transplantation ways in rat experiments of bone marrow mesenchymal stem cells weresummarized and compared in order to provide reference for scientific research. More mature transplant means are expected to promotethe progress of the experimental study of bone marrow mesenchymal stemcells.