Ghrelin对心肌梗死大鼠恶性心律失常和早期左室重构的影响(英文)

目的:本文主要研究ghrelin对心肌梗死大鼠恶性心律失常和早期左室重构的影响。方法:心肌梗死大鼠模型每天两次注射ghrelin(100μg/kg)或生理盐水。通过超声心动图评估大鼠的心脏重量并且观察大鼠的血流动力学。使用酶免疫分析法测定血清胰岛素生长因子I(IGF-1)、血浆肾上腺素、去甲肾上腺素和多巴胺的浓度。注射药物前后分析大鼠的神经功能。结果:与对照组相比,ghrelin治疗的心肌梗死模型大鼠生存率显著增加(P0.05),心脏功能增强,但心肌梗死面积差异不大(P0.05)。结论:Ghrelin能够提高心肌梗死模型大鼠的生存率、缓解心肌梗死大鼠心率失常、改善心肌梗死大鼠左心室重构。

Ghrelin Prevents Malignant Arrhythmia and Early Left Ventricular Remodeling in Rats with Myocardial Infarction

Objective:To investigate the effects of ghrelin on the cardiovascular system in rats with myocardial infarction (MI),such as preventing malignant arrhythmia, delaying left ventricular remodeling and decreasing mortality.Methods:Ghrelin (100 ug/kg sc,twice daily) or saline were administered for 2 weeks from the day of MI operation in Wistar rats. The effects of ghrelin on cardiacremodeling were evaluated by echocardiographic and hemodynamic. Serum insulin-like growth factor I (IGF-I), plasma concentrations ofepinephrine, norepinephrine, and dopamine were measured by using enzyme immunoassay kit. Before and after ghrelin (100 ug/kg sc)was administered in conscious rats with MI, the autonomic nervous function was investigated by power spectral analysis obtained by atelemetry system.Results:Results showed that compared with that in the control group rats, the percent survival of ghrelin treated ratsincreased significantly (P< 0.05), the cardiac function enhanced remarkably, but the size of the infarct of the left ventricular wall did notsignificantly differ between MI + NS rats and MI + Ghrelin rats (P> 0.05).Conclusion:Ghrelin can increase the survival rate, improvecardiac arrythmias and alleviate left ventricular remodeling of myocardial infarction rats.