脂联素的研究进展及与多种疾病的关系

超重和肥胖对心血管疾病,糖尿病及其它疾病的发生发展及预后有着重要的意义。脂联素是脂肪细胞介导的分泌蛋白,在体内和体外的大量实验中,都被证实具有多种功能:抗炎、改善胰岛素抵抗、抗动脉粥样硬化、降血糖、降血脂、抗氧化等。作为生物标记物,脂联素在临床研究中受到广泛关注。根据最新的研究结果,本文简要的介绍了脂联素的主要结构特征,作用机制,参与胰岛μ细胞的功能和存活、胰岛素抵抗的作用,以及与多种疾病之间的关系。作为唯一一个在肥胖患者体内水平下调的脂肪因子,脂联素对肥胖症、糖尿病、心血管疾病、肾脏疾病的保护作用及其分子机制的研究具有深远的意义,为相关疾病的预防和治疗提供新的思路。同时相关研究也为药物治疗提供可靠的下游靶点。

The Adiponectin Study Progress and Relationships with Diseases

Obesity and overweight constitute a world problem reaching epidemic proportions and impacting on the risk andprognosis of several disease states including cardiovascular disease, diabetes, and common forms of diseases. Adiponectin is anadipocyte-derived secretory protein. This adipokine attracts extensive attention because of its different functions. It is also widelyaccepted as a biomarker in clinical studies. Based on recent advance, we briefly introduce the major properties of this molecule,functional involvement in pancreatic beta cell and insulin resistance, as well as the association with diabetes , cardiovascular disease andkidney disease, so as to provide a new insight for the diagnosis, treatment and prevention of related diseases.