Wnt/beta-catenin 通路在成骨细胞中的作用

Wnt信号通路包括经典通路和非经典通路两种,其中Wnt经典通路又称为Wnt/β-catenin通路,其在成骨细胞的分化、增殖过程中发挥这重要的作用。Wnt信号通路实现过程中有多种因子参与,包括Wnt蛋白、β-catenin、蛋白激酶GSK-3β以及APC蛋白等多种。Wnt蛋白家族是由19种Wnt蛋白组成的,主要分为经典Wnt蛋白和非经典Wnt蛋白,其本质是一系列高度保守的分泌性糖蛋白,并且不同的Wnt蛋白对成骨细胞发挥着不同的作用,其中经典Wnt蛋白通过经典Wnt信号作用于成骨细胞对成骨细胞的增殖、分化有着重要的影响。本综述通过对Wnt经典信号通路过程中的多种因子与成骨细胞分化、增殖的关系进行分析总结,了解Wnt/β-catenin通路对成骨细胞的作用。

Role of Osteoblasts in Wnt / beta-catenin Pathway

Wnt signaling pathway was consisted of the classical pathway and non-classical pathway, wherein the Wnt pathwayis also called the classical Wnt / beta-catenin pathway, in which the proliferation may play an important role in the differentiation ofosteoblasts. Wnt signaling pathway was involved in the process of a variety of factors which includes the Wnt proteins, the beta-catenin, a protein kinase GSK-3beta and the APC protein. Wnt protein family is composed of 19 kinds of Wnt proteins, mainly divided into canonical Wnt proteins and non-canonical Wnt proteins, which is essentially a series of highly conserved secreted glycoproteins, and is different onosteoblasts, where the proliferation of canonical Wnt canonical Wnt signaling protein by acting on osteoblasts on osteoblastdifferentiation has important implications. This review aims at the classic Wnt signaling pathway by a variety of factors and the process of osteoblast differentiation and proliferation were analyzed and summarized the relationship, understanding the role of Wnt / beta-catenin pathway in osteoblasts.