IL-17 and Th17 cells in human inflammatory diseases |
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| Institution: | 2. The Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon;3. Division of Research, Kaiser Permanente Northern California, Oakland, California;4. The Group Health Research Institute, Seattle, Washington;6. Fred Hutchinson Cancer Research Center, Seattle, Washington;5. Department of Oncology, Kaiser Permanente Colorado, Denver, Colorado;1. Department of physiology, université Paris V René-Descartes, 15, rue de l’École-de-médecine, 75270 Paris cedex 06, France;2. Service de gastroentérologie, hôpital Avicenne, 125, rue de Stalingrad, 93009 Bobigny cedex, France;3. Département de chirurgie, faculté de médecine, CHUS-Hôtel-Dieu, université de Sherbrooke, 580, rue Bowen-Sud, Sherbrooke, J1G2EB Quebec, Canada;1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China;2. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China;4. Current affiliation: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China |
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| Abstract: | IL-17 was discovered in 1995/96 as a T cell derived cytokine with effects on inflammation and neutrophil activation. In 2006, the precise cell source of IL-17 was identified in the mouse, and these cells were named Th17 cells. They play a role in various human diseases associated with inflammation and destruction such as rheumatoid arthritis, psoriasis, Crohn's disease, multiple sclerosis, where IL-17 can be seen as a therapeutic target. |
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