Proteases and bone remodelling |
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| Institution: | 1. Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, EA 3822, Nantes F-44035 France;2. INSERM, ERI 7, Nantes F-44035, France;3. Université d’Angers, IUT, France;4. Centre Hospitalier Universitaire de Nantes, France;3. Institute of Biology of Ecole Normale Supérieure, 75005 Paris,;4. INSERM, U1024, 75005 Paris,;6. University Claude Bernard Lyon 1, Centre de Génétique et de Physiologie Moléculaire et Cellulaire (CGphiMC) UMR CNRS 5534, 69622 Villeurbanne, and;5. Institut Jacques Monod UMR CNRS 7592, 75013 Paris, France;1. Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, D-70569 Stuttgart, Germany;2. Department of Biophysical Chemistry, University of Heidelberg, INF 253, D-69120 Heidelberg, Germany;3. CNRS-UMR 5628, LMGP, 3 parvis L.Néel, F-38 016 Grenoble, France;4. University Grenoble Alpes, Grenoble Institute of Technology, LMGP, 3 parvis Louis Néel, F-28016 Grenoble, France;5. INSERM U823, ERL CNRS5284, Université de Grenoble Alpes, Institut Albert Bonniot, Site Santé, BP170, 38042 Grenoble cedex 9, France;1. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;2. Karamay Hongyou Software CO., LTD, Karamay 834000, China;1. Parasite Cell Biology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia;2. School of Veterinary Sciences, The University of Queensland, Gatton, 4343, Australia;3. School of Medical Sciences, Universiti Sains Malaysia, 16150, Kelantan, Malaysia;4. Division of Mycobacterial Research, National Institute for Medical Research, London, NW7 1AA, UK;5. Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia |
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| Abstract: | Bone remodelling is regulated by osteogenic cells which act individually through cellular and molecular interaction. These interactions can be established either through a cell–cell contact, involving molecules of the integrin family, or by the release of many polypeptidic factors and/or their soluble receptor chains. Proteolytic shedding of membrane-associated proteins regulates the physiological activity of numerous proteins. Proteases located on the plasma membrane, either as transmembrane proteins or anchored to cell-surface molecules, serve as activators or inhibitors of different cellular and physiological processes. This review will focus on the role of the proteases implicated in bone remodelling either through the proteolytic degradation of the extracellular matrix or through their relations with osteogenic factors. Their implication in bone tumor progression will be also considered. |
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