Filarial infection induces protection against P. berghei liver stages in mice |
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| Affiliation: | 1. Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany;2. Institute of Molecular Medicine and Experimental Immunology, University Hospital Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany;1. Department of Pathobiological Sciences, LSU School of Veterinary Medicine, Louisiana State University, 1909 Skip Bertman Drive, Baton Rouge, LA 70803, USA;2. Department of Pediatrics and Tropical Medicine, Baylor College of Medicine, Texas Children Hospital, 1102 Bates St., Ste.550, Houston, TX 77030, USA;3. Department of Microbiology and Immunology, Thomas Jefferson University, 233 S. 10th Street, Philadelphia, PA 19107, USA;4. Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, 310 E 67th St., New York, NY 10065, USA;1. Institute of Infection & Global Health, University of Liverpool, Liverpool, L3 5RF, UK;2. Cameroon Academy of Sciences, Yaoundé BP 1457, Cameroon;1. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Malawi;2. Department of Paediatrics, University of Malawi College of Medicine, Malawi;3. Liverpool School of Tropical Medicine, UK;4. Institute of Infection and Global Health, University of Liverpool, UK;5. Blantyre Malaria Project, University of Malawi College of Medicine, Malawi;6. College of Osteopathic Medicine, Michigan State University, East Lansing, MI, United States;7. School of Medicine, University of St. Andrews, UK;8. University College London, UK;1. Department of Microbiology and Immunology, Program in Global Oncology at the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA;1. Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA;2. Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, OH, USA;3. Department of Pediatrics, Cincinnati Children''s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA;4. Center for Autoimmune Genomics and Etiology, Division of Biomedical Informatics and Division of Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA;3. Department of Life Science, Center for Fungal Pathogenesis, Seoul 156-756, Korea;5. College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea;4. Department of Biotechnology, Center for Fungal Pathogenesis, Yonsei University, Seoul 120-749, Korea |
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| Abstract: | Chronic helminth infections such as filariasis in human hosts can be life long, since parasites are equipped with a repertoire of immune evasion strategies. In many areas where helminths are prevalent, other infections such as malaria are co-endemic. It is still an ongoing debate, how one parasite alters immune responses against another. To dissect the relationships between two different parasites residing in the same host, we established a murine model of co-infection with the filarial nematode Litomosoides sigmodontis and the malaria parasite Plasmodium berghei (ANKA strain). We found that filarial infection of BALB/c mice leads to protection against a subsequent P. berghei sporozoite infection in one-third of co-infected mice, which did not develop blood-stage malaria. This finding did not correlate with adult worm loads, however it did correlate with the presence of microfilariae in blood. Interestingly, protection was abrogated in IL-10-deficient mice. Thus, murine filariasis, in particular when it is a patent infection, is able to modify the immunological balance to induce protection against an otherwise deadly Plasmodium infection and is therefore able to influence the course of malaria in favour of the host. |
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