12th international TNF conference: The good,the bad and the scientists |
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| Affiliation: | 1. Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan;2. Department of Molecular Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan;1. Protective and Therapeutic Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute GEBRI, City for Scientific Research and Technology Applications, New Borg EL Arab, 21934 Alexandria, Egypt;2. Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, P.O. Box 80203, Jeddah 21589, Saudi Arabia;3. Department of Molecular Medicine and USF Health Byrd Alzheimer''s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA;4. Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia |
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| Abstract: | Members of the TNF superfamily control numerous aspects of immune defense as well as various processes of homeostasis and embryonic development. Recent advances in our knowledge of both the beneficial and the deleterious activities of these cytokines were thoroughly discussed at this conference. Participants presented new information about signaling mechanisms that these cytokines activate, with special attention to cell-death regulation, ubiquitination of signaling-proteins as a means of regulating their function, and complex systems of gene and signaling regulation. Sessions were devoted specifically to aberrations in functions of the TNF-family that contribute to the pathology of infectious, autoimmune and neurodegenerative diseases and to cancer, and to the application of our knowledge to therapy. |
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