Comparison of Pheochromocytomas and Abdominal and Pelvic Paragangliomas with Head and Neck Paragangliomas |
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| Institution: | 1. Section of Endocrinology, Department of Medicine, Riyadh, Saudi Arabia.;2. Department of Otolaryngology, Head and Neck Surgery, and Communication Sciences, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.;1. Fluminense Federal University - Institute of Computing, Niterói, RJ, Brazil;2. Federal Rural University of Pernambuco, Garanhuns, PE, Brazil;1. Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l''Information Médicale, ISSPAM, Marseille, France;2. Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pierre Louis d''Epidémiologie et de Santé Publique, Paris, France;3. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Antoine, Unité de Santé Publique, Paris, France;4. Université de Paris; AP-HP, Hôpital Cochin, Département d''Hépatologie; INSERM U1223, Institut Pasteur, Paris, France;5. AP-HP, Hôpital Cochin, Département d''Hépatologie, Paris, France;6. INSERM U1223, Institut Pasteur; Université Paris Descartes, Paris, France;1. Department of Management Science and Engineering, Donlinks School of Economics and Management, University of Science and Technology Beijing, Beijing, China;2. Department of Statistics, University of California, Berkeley, USA;3. Department of Automation, Tsinghua University, Beijing, China;4. Department of Statistics, Stanford University, USA;1. PETROBRAS, Rio de Janeiro, Brazil;2. Department of Electrical Engineering, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brazil |
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| Abstract: | ObjectiveTo compare clinical, radiologic, and pathologic characteristics, as well as management and outcomes, in a series of pheochromocytomas, abdominal and pelvic paragangliomas, and pelvic paragangliomas with head and neck paragangliomas.MethodsIn this retrospective study, we reviewed charts of all patients seen at our institution between January 1995 and December 2006. We searched pathology and medical record databases under the terms pheochromocytoma, paraganglioma, head and neck tumors, carotid body tumors, glomus jugulare, and neuroendocrine tumors. We compared clinical, radiologic, and pathologic characteristics, as well as management and outcomes, between patients with pheochromocytoma, abdominal and pelvic paraganglioma, and head and neck paraganglioma.ResultsEighty-six patients were included (46 with head and neck paraganglioma, 23 with pheochromocytoma, and 17 with abdominal or pelvic paraganglioma). Compared with patients with head and neck paraganglioma, patients with pheochromocytoma or abdominal and pelvic paraganglioma were younger (35.7 ± 16 years vs 43 ± 17 years, P = .042) and were more likely to have the classic triad associated with catecholamine hypersecretion of palpitation, excessive sweating, and headache (40% vs 0%, P < .001); hypertension (70% vs 37%, P = .005); and benign tumors (65% vs 43%, P = .03). Patients with head and neck paraganglioma and patients with pheochromocytoma/abdominal and pelvic paraganglioma were not different in female to male ratios (27:19 vs 29:11, respectively, P = .18), tumor size (5.8 ± 2.7 cm vs 5.7 ± 3 cm, respectively; P = .85), or remission rate (43% vs 60%, respectively, P = .13).ConclusionsHead and neck paraganglioma are similar to pheochromocytoma and abdominal and pelvic paraganglioma in size and outcome, but occur at an older age, lack hyperadrenergic manifestations, and are more likely to have local pressure effects and result in persistent disease. (Endocr Pract. 2009;15:194-202) |
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