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Engineering enzymes by ‘intelligent’ design
Affiliation:1. Metabolic Engineering Research Laboratory, Science and Engineering Institutes, Agency for Science, Technology and Research, Singapore;2. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States;1. The Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA;2. Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA;1. Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1868, USA;2. Department of Refractory Viral Infection, National Center for Global Health and Medicine Research Institute, 1-21-1 Toyama Shinjuku, Tokyo 162-8655, Japan;3. Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan;4. Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30307, USA;5. Department of Hematology, Rheumatology and Infectious Disease, Kumamoto University Graduate School of Biomedical Sciences, Kumamoto 860-0811, Japan;1. Department of Organic Chemistry, Faculty of Chemistry, University of Seville, C/ Profesor García González 1, 41012 Seville, Spain;2. Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan;3. Instituto de Química Avanzada de Cataluña, IQAC-CSIC. Jordi Girona 18–26, 08034 Barcelona, Spain;4. Instituto de Investigaciones Químicas (IIQ), CSIC – Universidad de Sevilla, C/ Américo Vespucio 49, Isla de la Cartuja, 41092 Seville, Spain;1. CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China;2. University of Chinese Academy of Sciences, Beijing, China
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