Consideration of a new catalytic role for the thiazolium sulfur atom of the coenzyme thiamine pyrophosphate |
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Authors: | John L. Hogg |
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Affiliation: | Department of Chemistry, Texas A&M University, College Station, Texas 77843 USA |
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Abstract: | A review of the mechanism of action of thiamine pyrophosphate is presented in brief detail along with a new proposal for the role of the sulfur atom of the thiazolium ring of the coenzyme. Evidence is presented to support the idea that sulfur plays a catalytic role in stabilizing negative charge developing in the transition states of the biological reactions. |
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