An approach to the semisynthesis of acyl carrier protein |
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| Authors: | R.L. Prestidge D.R.K. Harding C.H. Moore W.S. Hancock |
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| Affiliation: | Department of Chemistry, Biochemistry and Biophysics, Massey University, Palmerston North, New Zealand |
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| Abstract: | A scheme has been devised for the preparation of semisynthetic derivatives of acyl carrier protein (ACP). Acetylated synthetic ACP1–6 is coupled via its activated pentachlorophenol ester to native ACP (7–77), which had previously been acetylated and converted to the S-5′-dithiobis(2-nitrobenzoate)(DTNB) derivative. Removal of the DTNB moiety after the coupling yielded active ACP in good yield. |
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