Age related patterns of immunoglobulin serum levels in the Quechua Indians of Andean Mountains |
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| Authors: | S A Memeo L Piantanelli G Mazzufferi L Guerra M Nikolitz N Fabris |
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| Institution: | (1) Res. Dept. of the Istituto Riposo e Cura per Anziani, Center of Etnogeriatry, 60100 Ancona, Italy;(2) Res. Dept. of the Istituto Riposo e Cura per Anziani, Center of Biochemistry, 60100 Ancona, Italy;(3) Res. Dept. of the Istituto Riposo e Cura per Anziani, Center of Immunology, 60100 Ancona, Italy;(4) Electro Industrie  F. Scherrer , Periso Lab., Isone, Switzerland |
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| Abstract: | Age-dependent changes of IgA, IgG, IgM, and IgD serum levels in a population of Quechua Indians of Peruvian Andes at 4 300 m were investigated. A first increase and a subsequent decrease in IgA and IgM levels were observed with advancing age. IgG and IgD only display an increase during development. More or less pronounced sex-related changes were also found in all Ig classes, the sex dependent pattern of IgA being the more evident one. It has been suggested that sexual, genetic and environmental influences strongly superimpose to high altitude related changes in Ig profile during ageing. |
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