Synthetic water-soluble phenolic antioxidant regulates L-arginine metabolism in macrophages: A possible role of Nrf2/ARE |
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| Authors: | V O Tkachev E B Menshchikova N K Zenkov N V Kandalintseva N N Volsky |
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| Institution: | (1) H. Lee Moffitt Cancer Center and Research Institute and The Department of Interdisciplinary Oncology, University of South Florida, MRC 2067, 12902 Magnolia Dr, Tampa, 33612, FL,; |
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| Abstract: | Synthetic water-soluble phenolic antioxidant TS-13 exhibits pronounced anti-inflammatory properties in vivo and induces intracellular signal system Nrf2/ARE. At concentrations 150–1000 μM it inhibits nitric oxide (NO) production
in mouse peritoneal macrophages. However, this compound at low concentrations (1–100 μM) paradoxically increases NO production
and decreases activity of arginase. These results are indicative of an ambiguous role of NO and its metabolites in the mechanism
of development of inflammatory reaction. |
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