The effect of a rat plasma high-density lipoprotein subfraction on the synthesis of bile salts by rat hepatocyte monolayers |
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Authors: | R P Ford K M Botham K E Suckling G S Boyd |
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Affiliation: | Department of Biochemistry, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland |
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Abstract: | The effect of a rat high-density lipoprotein subfraction (HDL2) on the synthesis of bile salts by rat hepatocyte monolayers prepared from rats fed a diet containing cholestyramine, was investigated. The synthesis of bile salts as measured by radioimmunoassay of conjugated cholic, chenodeoxycholic and beta-muricholic acids was significantly increased when hepatocytes were incubated with a physiological concentration (500 micrograms HDL2 protein X ml-1) of HDL2. |
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