Ontogenesis of the alpha2-adrenergic receptor system in the hypothalamo-limbic system of the Pekin duck |
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Authors: | Andreas R Müller Rüdiger Gerstberger |
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Institution: | (1) Max-Planck-Institut für Physiologische und Klinische Forschung, W.G. Kerckhoff-Institut, Parkstrasse 1, D-61231 Bad Nauheim, Germany, DE |
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Abstract: | The development of the central nervous α2-adrenergic system in the duck was studied by semiquantitative autoradiography at the ontogenetic stages embryonic days 20
(E20) and 27 (E27) and postnatal days 3 (P3) and 14 (P14) by using the monoradioiodinated α2-agonist clonidine (125I]CLO) as radioligand. All structures endowed with α2-adrenoceptors in the adult animal were specifically labeled with 125I]CLO by E20. A detailed analysis of the binding capacity for 125I]CLO was performed for parts of several functional systems: hypothalamic structures (nucleus inferior hypothalami, nucleus
magnocellularis preopticus, nucleus paraventricularis), limbic system (habenula, nucleus septalis lateralis, nucleus striae
terminalis), circumventricular organs (organum pineale, organum subfornicale, plexus choroidei ventriculi tertii and ventriculi
lateralis), visual system (hyperstriatum accessorium, nucleus reticularis superior, tectum opticum), and associative cortex
(hyperstriatum ventrale). Except for the nucleus inferior hypothalami and the plexus choroideus ventriculi lateralis, all
structures showed a perinatal (E27–P3) maximum of α2-adrenoceptor-binding capacity with a subsequent decline to values of prehatching stages. This uniform expression pattern
of α2-adrenoceptors indicates that the days around hatching are a critical period for the development of the adrenergic system
in the brain of the duck.
Received: 21 March 1996 / Accepted: 4 July 1996 |
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Keywords: | : Alpha2-adrenoceptors Quantitative autoradiography Clonidine Hypothalamus Circumventricular organs Development ontogenetic Domestic mallard |
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