Current trends on cholinergic effect on secretion and activity of renin and angiotensin-converting enzyme

This article concerned to insufficiently studied subject on regulatory influence of cholinergic system on key parameters of renin-angiotensin system (renin and angiotensin converting enzyme activity and secretion). Literature data and author's investigations are considered. Influence of systemic and intrarenal infusions of acetylcholine, its analogues and antagonists, inhibition of vagal activity, denervation of kidney, increased and decreased parasympathetic tonus on renin and angiotensin converting enzyme secretion is discussed. Molecular mechanisms of acetylcholine influence on juxtaglomerular cells are considered. Regulatory significance of cholinergic influence on reninangiotensin system is discussed.