Age-related changes of elements with their relationships in human cranial and spinal nerves |
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Authors: | Masako Utsumi Setsuko Tohno Yoshiyuki Tohno Cho Azuma Yumi Moriwake Fumio Nishiwaki Masa-Oki Yamada Takeshi Minami |
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Institution: | (1) Laboratory of Cell Biology, Department of Anatomy, Nara Medical University, Kashihara, 634-8521 Nara, Japan;(2) Laboratory of Environmental Biology, Department of Life Science, Faculty of Science and Engineering, Kinki University, Higashi-Osaka, 577-8502 Osaka, Japan |
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Abstract: | To elucidate compositional changes of peripheral nerves with aging, the authors investigated age-related changes of elements
and their relationships in the optic, trigeminal, vagus, median, radial, ulnar, femoral, sciatic, tibial, and common peroneal
nerves by inductively coupled plasma-atomic emission spectrometry. The subjects consisted of 10 men and 12 women, ranging
in age from 65 to 91 yr. It was found that although accumulations of Ca and P occurred only in the trigeminal nerve at old
age, it hardly occurred in the optic, vagus, median, radial, ulnar, femoral, sciatic, tibial, and common peroneal nerves at
old age. The average contents of Ca and P were three and two times higher in the trigeminal nerve than in the other nine kinds
of nerve, respectively. Likewise, the average content of Mg was a little higher in the trigeminal nerve compared with the
other nerves.
With regard to the relationships among elements, significant direct correlations were found among the contents of Ca, P, S,
and Mg in most, but not all, 10 kinds of nerve. In the trigeminal nerve, a significant inverse correlation was found between
the contents of S and the other elements, such as Ca, P, and Mg. Regarding the relationships between the contents of S and
other elements, the nerves, except for the trigeminal nerve, differed from those found in the arteries previously reported. |
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Keywords: | Nerve cranial nerve spinal nerve trigeminal nerve calcium magnesium aging |
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