Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow |
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Authors: | Jean-Pierre Pelletier Johanne Martel-Pelletier Jean-Pierre Raynauld |
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Institution: | (1) Osteoarthritis Research Unit, Notre-Dame Hospital, University of Montreal Hospital Centre, Montreal, Quebec, Canada |
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Abstract: | Osteoarthritis (OA), the most common of all arthritic conditions, is a social and financial burden to all nations. The most
recent research has significantly advanced our understanding of the cause of OA and risk factors associated with it. These
findings have provided useful information that has helped in the daily management of patients with OA. Some preventative measures
and a number of therapeutic agents and drugs are available, which may help to reduce the progression of OA in certain patients.
Moreover, the most recent progress in research has significantly enhanced our knowledge of the factors involved in the development
of the disease and of the mechanisms responsible for its progression. This has allowed identification of several new therapeutic
targets in a number of pathophysiological pathways. Consequently, the field is opening up to a new era in which drugs and
agents that can specifically block important mechanisms responsible for the structural changes that occur in OA can be brought
into development and eventually into clinical trials. |
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