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Functional correlates of Apolipoprotein E genotype in Frontotemporal Lobar Degeneration |
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| Authors: | Barbara Borroni Daniela Perani Silvana Archetti Chiara Agosti Barbara Paghera Giuseppe Bellelli Monica Di Luca Alessandro Padovani |
| Institution: | 1. Department of Neurology, Centre for Aging Brain and Neurodegenerative Disorders, University of Brescia, Brescia, Italy 2. Vita-Salute H San Raffaele University, IRCCS H San Raffaele, Institute of Bioimaging and Molecular Physiology, Milan, Italy 3. Department of Laboratories and Diagnostics, University of Brescia, Brescia, Italy 4. Nuclear Medicine, Brescia Hospital, Brescia, Italy 5. Geriatric Unit, "Ancelle della Carità" Hospital, Cremona, Italy 6. Centre of Excellence for Neurodegenerative Disorders and Department of Pharmacology, University of Milan, Milan, Italy |
| Abstract: | BackgroundIt has been recently demonstrated that in Frontotemporal Lobar Degeneration (FTLD) memory deficits at presentation are commoner than previously thought. Apolipoprotein E (ApoE) genotype, the major genetic risk factor in sporadic late-onset Alzheimer Disease (AD), modulates cerebral perfusion in late middle-age cognitively normal subjects. ApoE ε4 homozygous have reduced glucose metabolism in the same regions involved in AD. |
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