Defective bursa regeneration after irradiation of young thymectomized chickens |
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| Authors: | B S Bhogal D S Chi J E Galton M K Bell G J Thorbecke |
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| Institution: | 1. Department of Pathology, New York University Medical Center, New York, New York 10016 U.S.A.;2. The Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, Tennessee 37601 U.S.A. |
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| Abstract: | The ability of the bursa of Fabricius to regenerate after gamma-irradiation and bone marrow reconstitution was examined in chickens thymectomized (TX) immediately after hatching. Irradiation (2 X 500 R) 3 weeks after hatching was followed by impaired bursa regeneration, as judged both by bursa/body weight ratios and by bursa follicle development 3-6 weeks later in TX as compared to control birds. Germinal center formation in the spleen was deficient, and immune responses to sheep erythrocytes (SRBC) and B. abortus (BA) were moderately reduced in the TX as compared to control birds irradiated at 3 weeks but not in TX birds irradiated at 5 weeks of age. |
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| Keywords: | All correspondence to Dr G J Thorbecke Department of Pathology New York University Medical Center 550 First Avenue New York New York |
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