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Predictable cholesterol binding sites in GPCRs lack consensus motifs
Authors:Geoffrey J. Taghon  Jacob B. Rowe  Nicholas J. Kapolka  Daniel G. Isom
Affiliation:1. Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, RMSB 6078A, Miami, FL 33136, USA;2. University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA;3. University of Miami Institute for Data Science and Computing, Miami, FL 33136, USA
Abstract:
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  • Keywords:G protein-coupled receptors (GPCRs)  cholesterol  cholesterol consensus motif (CCM)  cholesterol recognition/interaction amino acid consensus (CRAC) motif  lipids  structural informatics  X-ray diffraction  cryo-electron microscopy (cryo-EM)
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