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Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies
Authors:Gabriele Cerutti  Micah Rapp  Yicheng Guo  Fabiana Bahna  Jude Bimela  Eswar R Reddem  Jian Yu  Pengfei Wang  Lihong Liu  Yaoxing Huang  David D Ho  Peter D Kwong  Zizhang Sheng  Lawrence Shapiro
Institution:1. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA;2. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10029, USA;3. Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA;4. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Abstract:
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  • Keywords:B  1  351 and B  1  1  7 variants  COVID-19  cryo-EM  low-frequency immune response  neutralizing antibody  receptor-binding domain  SARS-CoV-2
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