Mesenchymal stem cell-derived small extracellular vesicles in the treatment of human diseases: Progress and prospect |
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Authors: | Jie Shi Yu-Chen Zhao Zhi-Fang Niu Hao-Jun Fan Shi-Ke Hou Xiao-Qin Guo Lu Sang Qi Lv |
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Affiliation: | Jie Shi, Yu-Chen Zhao, Hao-Jun Fan, Shi-Ke Hou, Xiao-Qin Guo, Lu Sang, Qi Lv, Institute of Disaster Medicine, Tianjin University, Tianjin 300072, ChinaJie Shi, Yu-Chen Zhao, Hao-Jun Fan, Shi-Ke Hou, Xiao-Qin Guo, Lu Sang, Qi Lv, Department of Biomaterials and Regenrative Medicine, Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin 300072, ChinaZhi-Fang Niu, General Hospital, Tianjin Medical University, Tianjin 300052, China |
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Abstract: | Mesenchymal stem cells (MSCs) are self-renewing, multipotent cells that could differentiate into multiple tissues. MSC-based therapy has become an attractive and promising strategy for treating human diseases through immune regulation and tissue repair. However, accumulating data have indicated that MSC-based therapeutic effects are mainly attributed to the properties of the MSC-sourced secretome, especially small extracellular vesicles (sEVs). sEVs are signaling vehicles in intercellular communication in normal or pathological conditions. sEVs contain natural contents, such as proteins, mRNA, and microRNAs, and transfer these functional contents to adjacent cells or distant cells through the circulatory system. MSC-sEVs have drawn much attention as attractive agents for treating multiple diseases. The properties of MSC-sEVs include stability in circulation, good biocompatibility, and low toxicity and immunogenicity. Moreover, emerging evidence has shown that MSC-sEVs have equal or even better treatment efficacies than MSCs in many kinds of disease. This review summarizes the current research efforts on the use of MSC-sEVs in the treatment of human diseases and the existing challenges in their application from lab to clinical practice that need to be considered. |
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Keywords: | Mesenchymal stem cells Small extracellular vesicles Exosomes Human diseases Therapeutics Prospects |
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