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The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex
Authors:Morgan Hepburn  Daniel J Saltzberg  Linda Lee  Shujuan Fang  Claire Atkinson  Natalie CJ Strynadka  Andrej Sali  Susan P Lees-Miller  David C Schriemer
Institution:1. Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada;2. Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Sciences, and California Institute for Quantitative Biomedical Sciences, University of California, San Francisco, CA 94158, USA;3. Department of Biochemistry and Molecular Biology and High-Resolution Macromolecular Electron Microscopy Facility, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada;4. Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada;5. Department of Chemistry, University of Calgary, Calgary, AB, Canada
Abstract:
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  • Keywords:DNA repair  non-homologous end-joining  DNA-PK  structure  synaptic complex  crosslinking mass spectrometry  hydrogen/deuterium exchange  modeling
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